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Tolerance Develops to the Sympathomimetic But Not the Local Anesthetic Effects of Cocaine
Wilson, Lance. et al. 2000. Tolerance Develops to the Sympathomimetic But Not the Local Anesthetic Effects of Cocaine. Journal of Toxicity: Clinical Toxicology. Vol 38 (7): 719.
The objective of this study was to obtain the effects of cocaine in the tolerance development of the sympathomimetic and the tolerance development to the local anesthetic. Twelve mixed-sex mongrel dogs, with the mean body weight of 17.7 kg were randomized to receive six, 5.25 mg/kg doses of cocaine. Arterial pressure, electrocardiogram, and serum cocaine were measured at control group, then at fixed time intervals of 15 minutes after each doses of cocaine or placebo. Each dog was given an intramuscular injection of morphine sulfate, 1.5 mg/kg, for sedation and anesthetized with an intravenous injection of alph...
Wilson, Lance. et al. 2000. Tolerance Develops to the Sympathomimetic But Not the Local Anesthetic Effects of Cocaine. Journal of Toxicity: Clinical Toxicology. Vol 38 (7): 719.
The objective of this study was to obtain the effects of cocaine in the tolerance development of the sympathomimetic and the tolerance development to the local anesthetic. Twelve mixed-sex mongrel dogs, with the mean body weight of 17.7 kg were randomized to receive six, 5.25 mg/kg doses of cocaine. Arterial pressure, electrocardiogram, and serum cocaine were measured at control group, then at fixed time intervals of 15 minutes after each doses of cocaine or placebo. Each dog was given an intramuscular injection of morphine sulfate, 1.5 mg/kg, for sedation and anesthetized with an intravenous injection of alph...
Posted by: Shelia Olander
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