Molecular Biology outline

Raji cells


Cell line that grows in suspension derived from patient with Burkitt&’s lymphoma

lymphoblast


Often referred to as a blast cell. Unlike other usages of the suffix -blast a lymphoblast is a further differentiation of a lymphocyte, T- or B-, occasioned by an antigenic stimulus. The lymphoblast usually develops by enlargement of a lymphocyte, active re-entry to the S phase of the cell cycle, mitogenesis and production of much m-RNA and ribosomes.

Burkitt's lymphoma


Malignant tumour of lymphoblasts derived from B-lymphocytes. Most commonly affects children in tropical Africa: both Epstein-Barr virus and immunosuppression due to malarial infection are involved.

yeast-2-hybrid interactions
All two-hybrid screening systems rely on the fact that transcriptional activation and DNA-binding domains of transcription factors are modular in nature6, 7. In these systems, the coding sequence for the DNA-binding domain of a transc...