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Back to category: Science Limited version - please login or register to view the entire paper. Breast Cancer: BRCA1 and BRCA2 Mutations Genetics and the Predisposition to Breast Cancer: BRCA1 & BRCA2 I. A. The genetics of Cancer a. Some Interesting Facts i. Cancer is one of the most common and severe diseases on earth ii. It is responsible for 20% of all deaths iii. One-third of the world’s population will develop some form of cancer iv. Cancer is responsible for more than 10% of the total cost of all medical care in developed countries b. Cancer is a virulent form of neoplasia, or uncontrolled cellular proliferation leading to a malignant mass or tumor capable of metastasizing. c. Three main forms of cancer: Lymphoid/hematopoietic, sarcoma, carcinoma. B. Molecular basis of cancer a. Mutations in the genes responsible for controlling cell proliferation and apoptosis cause cancer. b. Damage to the DNA of a somatic cell rarely has an effect beyond that cell unless the mutation contributes to a malignant transformation (cancer). c. Cancer results from a se... Posted by: Raymon Androckitis Limited version - please login or register to view the entire paper. |
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