Microbiology

MICROBIOLOGY REVIEW SHEET


Chemotherapy is often used for:
-cancer recurrences
-older people
-people with good prognosis without chemotherapy

Therapy: Toxic to:
Cytotoxic chemo + Radiation All cells (faster growing more so)
Radioactive Iodine Thyroid cell (faster growing)
The DREAM All Cancer cells
¡§Molecular Target Drugs Particular patients cancer with its particular mutation (s)

All your cells have growth switches
Mutation may leave the switches stuck OFF Cell doesn¡¦t grow, it dies
Mutation may leave the switches stuck ON Cell keeps growing when it shouldn¡¦t

Cells receive signals telling them when to grow. Cells grow when grow factor tickles the receptor. Ex: ¡§Her2 receptor¡¨
Switch ON: Too sensitive ¡V always getting signal to grow (mutation).
Switch OFF: Growth factor has nothing to tickle.

Herceptin: ¡§Targets¡¨ (blocks) receptors. Cancer cells do not receive growth signal

25% of breast cancers ...