Healing skin and Surrounding Nerves

This study was conducted in order to investigate the relationship between wound healing of skin and their surrounding nerves and how this relationship is reciprocal. Wounds were made on embryos at different stages of development and some embryos studied had no nerves in the area of the wound site. Other studies have suggested that the rate of wound healing is dependent on nerves and that the wound sites become hyperinnervated by sensory nerves during healing. On the other hand, the authors want to confirm that wound healing does not trigger hyperinnervation in the embryo as it does in adults.

Fertilized White Leghorn chicken eggs were used and incubated until they reached the embryonic stage 4 (E4) and/or E7. Chick embryos are a good choice because wound healing can occur without scarring or inflammation, which could have an effect on the results. The wing bud was chosen as the site of incision because it is easily accessible for microsurgery and because the nerve pattern ...