Depression

Biochemical Correlates of Depression
Research clearly points to a link between depression and biochemical abnormalities in the brain. While much is still to be discovered, evidence strongly suggests that abnormalities in the synaptic transmitter systems of the brain can cause depression.
Two neurotransmitters thought to have significant importance are norepinephrine and serotonin. Depression is usually associated with the reduction in levels of serotonin and norepinephrine, although other neurotransmitters may be involved. Reduced levels of serotonin in the synapse have been associated to cause depression. However, many other factors are involved. Recent studies suggest that a complex system, involving second messenger systems, in which secondary chemicals affect the synthesis and transport of primary neurotransmitters, such as serotonin also play a role. But, it was the research into primary neurotransmitter systems that led the revolution in the treatment of depression during ...