Atherosclerosis

A Review and discussion of the evidence for a genetic link to Atherosclerosis"

Introduction:
Atherosclerosis is a disease more commonly referred to as a 'Hardening of the arteries' (1), and is the major cause of morbidity and mortality in the western world (2). It is believed to be a multifactorial process, which can in some cases start in utero (3). Patients with atherosclerosis represent a heterogenous group of individuals, with diseases that progress at significantly different rates and in distinctly different patterns (5). It is described by the deposition of fatty material (atherosclerotic plaques) in, not on, arterial vessel walls - due to an excess in-flow of cholesterol. This can lead to occlusion of the artery - in most cases this occurs due to a sudden rupturing of the plaque that triggers the emergence of a blood clot/thrombus that blocks blood flow (as oppose to direct occlusion by the plaque) leading to complications such as strokes or heart attacks (1/4).
There...